发明名称 |
METHOD FOR OBTAINING BIOLOGICALLY ACTIVE RECOMBINANT HUMAN G-CSF |
摘要 |
Provided is a method of obtaining biologically active recombinant human G-CSF from inclusion bodies, wherein the solubilization and refolding process can be performed at ambient temperature and the purification step comprises reversed phase chromatography (RP), in particular RP-HPLC. The G-CSF preparation so obtained is characterized by high purity and homogeneity.
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申请公布号 |
US2012328560(A1) |
申请公布日期 |
2012.12.27 |
申请号 |
US201113634801 |
申请日期 |
2011.03.17 |
申请人 |
HINDERER WALTER;SCHECKERMANN CHRISTIAN;BIOGENERIX AG |
发明人 |
HINDERER WALTER;SCHECKERMANN CHRISTIAN |
分类号 |
C07K1/20;A61K38/19;C07K14/535 |
主分类号 |
C07K1/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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