发明名称 |
Fusion Polypeptides Capable of Activating Receptors |
摘要 |
A fusion polypeptide comprising (A)x-M-(A′)y, wherein A and A′ are each polypeptides capable of binding a target receptor. The fusion polypeptides of the invention form multimeric proteins which activate the target receptor. A and A′ may be each be an antibody or fragment derived from an antibody specific for a target receptor, such as the same or different scFv fragments, and/or a ligand or ligand fragment or derivative capable of binding the target protein, M is a multimerizing component, and X and Y are independently a number between 1-10.
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申请公布号 |
US2013034553(A1) |
申请公布日期 |
2013.02.07 |
申请号 |
US201213628082 |
申请日期 |
2012.09.27 |
申请人 |
REGENERON PHARMCEUTICALS, INC.;REGENERON PHARMCEUTICALS, INC. |
发明人 |
FANDL JAMES P.;CHEN GANG;PAPADOPOULOS NICHOLAS J.;ALDRICH THOMAS H. |
分类号 |
C07K19/00;A61K39/395;A61P3/10;A61P9/10;A61P17/02;C07K16/46 |
主分类号 |
C07K19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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