发明名称 |
Methods and Tools for Screening Agents Exhibiting an Activity on Receptors of the Tumor Necrosis Factor Receptor Superfamily |
摘要 |
The present invention provides novel chimeric receptors and methods of screening using the chimeric receptors. The chimeric receptors comprise an extracellular domain of a tumor necrosis factor receptor superfamily (TNFRSF) receptor and an intracellular domain with kinase activity stemming from a receptor tyrosine kinase. According to an embodiment, the chimeric receptor comprises a full-length TNFRSF receptor. The present invention provides means for screening and testing of modulators of TNFRSF receptors.
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申请公布号 |
US2013079246(A1) |
申请公布日期 |
2013.03.28 |
申请号 |
US201113695918 |
申请日期 |
2011.05.05 |
申请人 |
DE SMEDT THIBAUT;GALIBERT LAURENT;VAN DER VUURST DE VRIES ANNE-RENEE;POUPARD KEVIN;ADDEX PHARMA SA |
发明人 |
DE SMEDT THIBAUT;GALIBERT LAURENT;VAN DER VUURST DE VRIES ANNE-RENEE;POUPARD KEVIN |
分类号 |
C12Q1/48;C12N9/96 |
主分类号 |
C12Q1/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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