AMORPHOUS MIXTURE OF LOPINAVIR AND RITONAVIR CO-PRECIPITATED ON COPOVIDONE

摘要

The present invention relates to amorphous mixture of lopinavir and ritonavir coprecipitated on copovidone, process for its preparation and pharmaceutical compositions comprising it. In one aspect, the present invention provides amorphous mixture of lopinavir and. ritonavir co-precipitated on copovidone. In another aspect, the present invention provides a process for the preparation of amorphous mixture of lopinavir and ritonavir co-precipitated on copovidone, which comprises: i) dissolving a mixture of lopinavir, ritonavir, copovidone, aerosil and span-20 in an alcoholic solvent; and ii) removing the solvent by drying at about 50 to 80°C to obtain amorphous mixture of lopinavir and ritonavir co-precipitated on copovidone.