| 摘要 |
A process for manufacturing a 2,3-disubstituted-5-methoxymethylpyridine of formula (I), where Z is H or halogen; Zis H, halogen, CN or NO; Yis OM, and M is an alkali metal or an alkaline earth metal, comprises the step of: (i) reacting a compound of formula (II) where Q is a tertiary aliphatic or cyclic, saturated, partially unsaturated or aromatic amine; Z is H or halogen; Zis H, halogen, CN or NO; Yand Yare each independently OR, NRR, or when taken together YYis-O-, -S- or -NR-; Rand Rare each independently H, C-Calkyl optionally substituted with C-Calkoxy or phenyl optionally substituted with one to three C-Calkyl groups, C-Calkoxy groups or halogen atoms, or phenyl optionally substituted with one to three C-Calkyl groups, C-Calkoxy groups or halogen atoms; Ris H or C-Calkyl, in a methanol/HO mixture, comprising at least 20 % by weight HO (based on the sum of water and bromide (II)), with a base comprising MOCHand/or MOH, where M is alkali metal or alkaline earth metal, under pressure in a closed vessel at a temperature of from 75 to . Compounds of formula (I) are useful intermediates in the synthesis of herbicidal imidazolinones, like imazamox. |
