| 发明名称 |
HYBRID DIAZENIUMDIOLATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHOD OF TREATING CANCER |
| 摘要 |
<p>Disclosed are hybrid compounds that release both nitric oxide and a moiety that inhibits poly (ADP-ribose) polymerase (PARP), e.g., a compound or a pharmaceutically acceptable salt thereof of formula (I), wherein R1-4 and m-p are as described herein. Also disclosed are pharmaceutical compositions and methods of use including treating cancer and enhancing the chemotherapeutic treatment of chemotherapeutic agents and high energy radiation.</p> |
| 申请公布号 |
CA2852682(A1) |
申请公布日期 |
2013.04.25 |
| 申请号 |
CA20122852682 |
申请日期 |
2012.10.18 |
| 申请人 |
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
MACIAG, ANNA E.;KEEFER, LARRY K.;SAAVEDRA, JOSEPH E.;JI, XINHUA;KUMARI, VANDANA |
| 分类号 |
C07D403/10;A61K31/496;A61P35/00;C07D237/26;C07D241/04 |
主分类号 |
C07D403/10 |
| 代理机构 |
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代理人 |
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