| 发明名称 |
PHARMACEUTICALLY ACCEPTABLE MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND THEIR METHODS OF IDENTIFICATION |
| 摘要 |
The present invention relates to mGluR5 positive allosteric modulators (PAM) and methods for identifying pharmaceutically acceptable compounds with high tolerability and safety, which method comprises the use of at least one non-competitive mGluR5 allosteric modulator which has a shift factor measured at 10 uM glutamate concentration below 3.0,
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| 申请公布号 |
US2013123254(A1) |
申请公布日期 |
2013.05.16 |
| 申请号 |
US201213616619 |
申请日期 |
2012.09.14 |
| 申请人 |
BIEMANS BARBARA;JAESCHKE GEORG;LINDEMANN LOTHAR;MUSTER WOLFGANG;STADLER HEINZ;VIEIRA ERIC |
发明人 |
BIEMANS BARBARA;JAESCHKE GEORG;LINDEMANN LOTHAR;MUSTER WOLFGANG;STADLER HEINZ;VIEIRA ERIC |
| 分类号 |
A61K31/5377;A61K31/44;A61K31/4439;A61K31/444;A61K31/4545;A61K31/501;A61K31/505;A61K31/506;A61K31/5355 |
主分类号 |
A61K31/5377 |
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