发明名称 |
USE OF ANTI THIRD PARTY CENTRAL MEMORY T CELLS FOR ANTI-LEUKEMIA/LYMPHOMA TREATMENT |
摘要 |
A method of treating a disease in a subject in need thereof is disclosed. The method comprising: (a) transplanting a non-syngeneic cell or tissue graft to the subject; and (b) administering to the subject a therapeutically effective amount of an isolated population of cells comprising non-graft versus host (GVHD) inducing anti-third party cells having a central memory T-lymphocyte (Tcm) phenotype, the cells being tolerance-inducing cells and capable of homing to the lymph nodes following transplantation, and further wherein the cells are either: (i) non-syngeneic with both the subject and the graft; or (ii) non-syngeneic with the graft and syngeneic with the subject, thereby treating the subject.
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申请公布号 |
US2013171108(A1) |
申请公布日期 |
2013.07.04 |
申请号 |
US201113821255 |
申请日期 |
2011.09.08 |
申请人 |
REISNER YAIR;LASK ASSAF;OPHIR ERAN;OR-GEVA NOGA;COHEN ADVA;AFIK RAN;BACHAR-LUSTIG ESTHER;EIDELSTEIN YAKI;YEDA RESEARCH AND DEVELOPMENT CO., LTD. |
发明人 |
REISNER YAIR;LASK ASSAF;OPHIR ERAN;OR-GEVA NOGA;COHEN ADVA;AFIK RAN;BACHAR-LUSTIG ESTHER;EIDELSTEIN YAKI |
分类号 |
A61K35/28;C12N5/071 |
主分类号 |
A61K35/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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