发明名称 |
EXENDIN-4 ANALOGUE PEGYLATED WITH POLYETHYLENE GLYCOL OR DERIVATIVE THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSTION FOR PREVENTING OR TREATING DIABETES, CONTAINING SAME AS ACTIVE INGREDIENT |
摘要 |
The present disclosure relates to an exendin-4 analogue PEGylated with polyethylene glycol or a derivative thereof, a preparation method, and a pharmaceutical composition for prevention or treatment of diabetes containing the same as an active ingredient. According to the present invention, the yield of an exendin-4 analogue can be increased via the selective PEGylation by using exendin-4 in which a cysteine is introduced into #40 site of the C-terminal, and treatment effect of medications can be increased, so that the exendin-4 analogue can be usefully applied as a composition for prevention or treatment of diseases caused by insulin hypersecretion.
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申请公布号 |
US2013217622(A1) |
申请公布日期 |
2013.08.22 |
申请号 |
US201213882361 |
申请日期 |
2012.06.28 |
申请人 |
LEE SUNG KWON;KIM WON BAE;LEE SEULKI;KIM TAE HYUNG;B & L DELIPHARM, CORP. |
发明人 |
LEE SUNG KWON;KIM WON BAE;LEE SEULKI;KIM TAE HYUNG |
分类号 |
A61K47/48 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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