发明名称 COMBINATION OF PARTIAL NICOTINE RECEPTOR AGONIST AND ACETYLCHOLINESTERASE INHIBITOR, PHARMACEUTICAL COMPOSITION CONTAINING THEM, AND USING IT FOR TREATING COGNITIVE DISORDERS
摘要 FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to a combination of a partial alpha 7 nicotine receptor agonist and a acetylcholiesterase inhibitor for treating cognitive disorders, differing by the fact that the partial alpha 7 nicotine receptor agonist is (2E)-but-2-endioatom 4-bromphenyl-1,4-diazabicyclo[3.2.2]nonane-4-carboxylate, and the acetylcholiesterase inhibitor is specified in rivastigmine and donepezil, to a pharmaceutical composition, to a set comprising the combination according to the invention and to using it in treating the cognitive disorders.EFFECT: what is shown is a better effect of the combination on the pro-cognitive pharmacological effect scale as compared to the effect provided by both active substances taken separately.7 cl, 5 dwg
申请公布号 RU2493851(C2) 申请公布日期 2013.09.27
申请号 RU20100154417 申请日期 2009.06.02
申请人 SANOFI-AVENTIS 发明人 BERZHI OLIV'E;PISHA FILIPP;JURANI ALEKSANDR
分类号 A61K31/551;A61K31/27;A61K31/445;A61P25/28 主分类号 A61K31/551
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