| 摘要 |
PURPOSE: A transdermal peptide is provided to promote body delivery of large drug molecules. CONSTITUTION: A pore penetration peptide is SSHTISF, FPQPPQR, AFTPAKT or SPWIPAV. The transdermal peptide is SSHTISF, FPQPPQR, AFTPAKT or SPWIPAV. The SSHTISF peptide is ST1 peptide(Ser-Ser-His-Thr-Ile-Ser-Phe). The FPQPPQR peptide is ST2 peptide(Phe-Pro-Gln-Pro-Pro-Gln-Arg). The AFTPAKT peptide is ST2 peptide(Ala-Phe-Thr-Pro-Ala-Lys- Thr). The SPWIPAV peptide is ST4 peptide(Ser-Pro-Trp-Ile-Pro-Ala-Val). [Reference numerals] (AA) Repeat of biopanning round(1-3 times); (BB) Random transdermal administration of phage-peptide library into rat; (CC) Blood collection through heart at predetermined time after administration to collect skin penetrating phage; (DD) Amplificatioin of phage mixture collected from E.coli ER2738; (EE) Selecting each recombinant phage from biopanning of third round and determining peptide-coding nucleotide sequence; (FF) Peptide sequence identification from nucleotide sequence |
