发明名称 |
Preparation of 4-amino-thiazoles and 3-amino-1,2,4-thiadiazoles and their use as allosteric modulators of metabotropic glutamate receptors |
摘要 |
The present invention relates to novel compounds of Formula (I), wherein M, P, X, A and (B)n are defined as in Formula (I); invention compounds are modulators of metabotropic glutamate receptors-subtype 4 ("mGluR4") which are useful for the treatment or prevention of central nervous system disorders as well as other disorders modulated by mGluR4 receptors. The invention is also directed to pharmaceutical compositions and the use of such compounds in the manufacture of medicaments, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR4 is involved. |
申请公布号 |
US8604033(B2) |
申请公布日期 |
2013.12.10 |
申请号 |
US201113520544 |
申请日期 |
2011.01.14 |
申请人 |
BOLEA CHRISTELLE;ADDEX PHARMA S.A. |
发明人 |
BOLEA CHRISTELLE |
分类号 |
A61K31/506;A61K31/4439;A61P1/00;A61P1/04;A61P3/00;A61P3/10;A61P25/00;A61P25/08;A61P25/14;A61P25/16;A61P25/18;A61P25/22;A61P25/24;A61P25/28;A61P25/30;A61P27/02 |
主分类号 |
A61K31/506 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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