| 摘要 |
PROBLEM TO BE SOLVED: To provide an isolated or purified polypeptide or a peptidomimetic used for treating or preventing cancer, treating a neoplasm or psoriasis.SOLUTION: There is provided a polypeptide or peptidomimetic comprising an amino acid sequence of a portion of a Smoothened (SMO) protein, comprising a functional fragment thereof, or a functional variant of either the portion or the functional fragment, or a fatty acid derivative thereof. Methods for inhibiting proliferation of a diseased cell, treating or preventing cancer, treating a neoplasm or psoriasis, and inhibiting the expression of genes involved in the Hedgehog signaling pathway, thereby inhibiting the Hedgehog signaling pathway, are furthermore provided by the invention. |
