发明名称 |
PYRAZINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHBITORS |
摘要 |
The present invention relates to compounds of the general formula (I) wherein R 1 , R 2 and R 3 are as defined herein, which can act as inhibitors of protein kinases, specially the Fms-like tyrosine kinase 3 (FLT3). The invention also relates to the use of the compounds in therapy, pharmaceutical compositions comprising the compounds and the use of the compounds for the preparation of a medicament for the prophylaxis and treatment of hematological malignancies, such as AML, MLL, T-ALL, B-ALL and CMML, myeloproliferative disorders, other proliferative disorders like cancer, autoimmune disorders and skin disorders like psoriasis and atopic dermatitis. |
申请公布号 |
EP2671876(A3) |
申请公布日期 |
2014.02.05 |
申请号 |
EP20130182880 |
申请日期 |
2009.01.28 |
申请人 |
AKINION PHARMACEUTICALS AB |
发明人 |
JENMALM JENSEN, ANNIKA;LEHMANN, FREDRIK;NILSSON,, BJOERN M;NORDLING, ERIK;PARROW, VENDELA |
分类号 |
C07D241/20;A61K31/4965;A61K31/497;A61K31/5415;A61P17/00;A61P35/00;C07D401/04;C07D401/14;C07D403/12;C07D407/14;C07D409/14;C07D417/14 |
主分类号 |
C07D241/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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