POLYENOLIC ZINC-BINDING AGENTS (PEZBINS) ACTIVELY PROMOTE INACTIVATION OF CANCER STEM CELLS AND POTENTIATE CYTOTOXIC ANTI-TUMOR DRUG SUBSTANCES

摘要

The present invention provides a method of inhibiting the growth of or promoting differentiation and destruction of cancer stem cells (CSCs) comprising contacting the cancer stem cells with a compound of the invention, including CMC2.24, or a pharmaceutically acceptable salt thereof. The present invention also provides a method of down-regulating cancer stem cell-relevant transcription factors comprising contacting the cancer stem cells with a compound of the invention, including CMC2.24, or a pharmaceutically acceptable