| 发明名称 |
SINGLE-PROTEIN NANOMECHANICAL MASS SPECTROMETRY IN REAL TIME |
| 摘要 |
Methods and devices relating to measuring a landing position and mass of an analyte adsorbed to a nanomechanical resonator by resolving adsorbate-induced frequency shifts in at least two modes of a resonator resonance frequency, where during the resolving of the frequency shifts in the at least two modes analysis is so that the transformation (G) from the fractional-frequency shift pair to the analyte mass-position pair is one-to-one. Complex protein mixtures can be analyzed at high sensitivity and resolution. |
| 申请公布号 |
US2014156224(A1) |
申请公布日期 |
2014.06.05 |
| 申请号 |
US201313890087 |
申请日期 |
2013.05.08 |
| 申请人 |
California Institute of Technology |
发明人 |
ROUKES Michael L.;HANAY Mehmet Selim;KELBER Scott;NAIK Akshay |
| 分类号 |
G01G9/00 |
主分类号 |
G01G9/00 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A method comprising:
measuring a landing position and mass of an analyte adsorbed to a nanomechanical resonator by resolving adsorbate-induced frequency shifts in at least two modes of a resonator resonance frequency, wherein during the resolving of the frequency shifts in the at least two modes analysis is so that the transformation (G) from the fractional-frequency shift pair to the analyte mass-position pair is one-to-one.
|
| 地址 |
Pasadena CA US |
