METHODS AND COMPOSITIONS FOR INHIBITING POLYOMAVIRUS-ASSOCIATED PATHOLOGY

摘要

Disclosed herein are methods of eliciting an immune response against a polyomavirus (for example, BKV serotype I (BKV-I), BKV serotype II (BKV-II), BKV serotype III (BKV-III) and/or BKV serotype IV (BKV-IV)) and methods of treating or inhibiting polyomavirus-associated pathology (such as polyomavirus-associated nephropathy, BKV-associated hemorrhagic cystitis, or JC virus-associated progressive multifocal leukoencephalopathy; PML). Further disclosed are immunogenic compositions of use in the disclosed methods. Also disclosed are methods of selecting an organ transplant donor and/or recipient including detecting whether the prospective donor and/or recipient has BKV serotype-specific (such as BKV serotype IV-specific) neutralizing antibodies.

主权项

1. A method of eliciting an immune response against a BK polyomavirus (BKV) in a subject, comprising administering to a subject in need of enhanced immunity to BKV:
a therapeutically effective amount of at least one isolated BKV serotype I (BKV-I) capsid polypeptide or a nucleic acid encoding the at least one BKV-I capsid polypeptide; and a therapeutically effective amount of at least one isolated BKV serotype IV (BKV-IV) capsid polypeptide or a nucleic acid encoding the at least one BKV-IV capsid polypeptide, wherein the at least one BKV-I capsid polypeptide and the at least one BKV-IV capsid polypeptide are different, thereby eliciting an immune response against the BKV.