发明名称 |
microRNAs FOR CARDIAC REGENERATION THROUGH INDUCTION OF CARDIAC MYOCYTE PROLIFERATION |
摘要 |
The present invention discloses a set of human microRNAs, or a primary transcript for such microRNAs, or a precursor of such microRNAs, or a mimic of such microRNAs or a combination thereof, and their use as medicaments for inducing proliferation of cardiomyocytes for the prevention and treatment of heart diseases associated with a loss of cardiomyocytes. The invention also relates to a method for screening microRNAs and biological and therapeutically active compounds for their ability to increase proliferation of cardiomyocytes. |
申请公布号 |
EP2794882(A1) |
申请公布日期 |
2014.10.29 |
申请号 |
EP20120823043 |
申请日期 |
2012.12.21 |
申请人 |
I.C.G.E.B. INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY |
发明人 |
GIACCA, MAURO;ZACCHIGNA, SERENA;CUNHA MANO, MIGUEL LUIS;BREGIEIRO EULALIO, ANA SOFIA |
分类号 |
C12N15/113;A61K31/713;A61P9/00 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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