CARBOSTYRIL DERIVATIVES AND SEROTONIN REUPTAKE INHIBITORS FOR TREATMENT OF MOOD DISORDERS

摘要

THE PHARMACEUTICAL COMPOSITION OF THE PRESENT INVENTION COMPRISES (1) A CARBOSTYRIL DERIVATIVE AND (2) A SEROTONIN REUPTAKE INHIBITOR IN A PHARMACEUTICALLY ACCEPTABLE CARRIER. THE CARBOSTYRIL DERIVATIVE MAY BE ARIPIPRAZOLE OR A METABOLITE THEREOF, WHICH IS A DOPAMINE-SEROTONIN SYSTEM STABILIZER. THE SEROTONIN REUPTAKE INHIBITOR MAY BE FLUOXETINE, DULOXETINE, VENLAFAXINE, MILNACIPRAN, CITALOPRAM, FLUVOXAMINE, PAROXETINE OR SERTRALINE. THE PHARMACEUTICAL COMPOSITION OF THE PRESENT INVENTION IS USEFUL FOR TREATING PATIENTS WITH MOOD DISORDERS, PARTICULARLY DEPRESSION OR MAJOR DEPRESSIVE DISORDER.