REGULATORY T CELLS AND METHODS OF IDENTIFYING, OBTAINING AND USING TO TREAT IMMUNO-BASED DISORDERS

摘要

The present specification discloses regulatory T cells, compositions including regulatory T cells, methods of identifying, isolating, enriching, obtaining, and/or expanding regulatory T cells or subset populations thereof, kits including components useful for performing such methods, and methods of treating an immune-based disorder in an individual by administering regulatory T cells or compositions comprising such regulatory T cells to an individual in need thereof.

主权项

1. A method of identifying a population of immunosuppressive regulatory T-cells, the method comprising:
screening a sample comprising a population of T-cells to detect a level of cellular expression of at least two different biomarkers, the at least two different biomarkers including a CD25 biomarker and a CD6 biomarker; wherein detection of a subpopulation of T-cells comprising a CD25+CD6low/− expression pattern identifies the population of immunosuppressive regulatory T-cells in the sample.