MESENCHYMAL STEM CELLS FOR IN VITRO MODELING AND CELL-BASED THERAPY OF HUMAN DISEASES AND BANKS THEREOF

摘要

A method of qualifying a mesenchymal stem cell (MSC) population is disclosed. The method comprises:
(a) ex vivo differentiating a population of mesenchymal stem cells originating from the subject towards a first lineage-specific cell, the first lineage-specific cell being associated with a brain disease;(b) ex vivo differentiating a population of mesenchymal stem cells originating from a healthy subject towards the first lineage-specific cell;(c) comparing an effect of the first lineage specific cell derived from the subject with an effect of the first lineage specific cell derived from the healthy subject on a second lineage specific cell associated with the brain disease, wherein a difference in the effect above or below a predetermined level is indicative of a qualification of a mesenchymal stem cell population for cell therapy of said brain disease.

主权项

1. A method of qualifying a mesenchymal stem cell (MSC) population, the method comprising:
(a) ex vivo differentiating a population of mesenchymal stem cells originating from the subject towards a first lineage-specific cell, said first lineage-specific cell being associated with a brain disease; (b) ex vivo differentiating a population of mesenchymal stem cells originating from a healthy subject towards said first lineage-specific cell; (c) comparing an effect of said first lineage specific cell derived from said subject with an effect of said first lineage specific cell derived from said healthy subject on a second lineage specific cell associated with the brain disease, wherein a difference in said effect above or below a predetermined level is indicative of a qualification of a mesenchymal stem cell population.