Novel 6-amino acid heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection

摘要

The invention provides novel compounds having the general formula:;;wherein R1, R2, R3, R4 and A are as described herein, compositions including the compounds and methods of using the compounds.

主权项

1. A compound of formula (I) wherein
R1 is C1-6alkyl or trifluoromethyl-CxH2—, wherein x is 1-6;One of R2 and R3 is phenyl, which is once or twice or three times substituted by C1-6alkyl, cyano or halogen; and the other one is hydrogen or deuterium;R4 is phenyl, thiazolyl, oxazolyl, imidazolyl, thienyl or pyridinyl, which is unsubstituted or substituted by C1-6alkyl, C1-6alkylsulfanyl, halogen or cycloalkyl, where said C1-6alkyl can be further optionally substituted with halogen;A iswhich is unsubstituted or substituted by groups selected from C1-6alkyl, deuterium and halogen;
or pharmaceutically acceptable salts, or enantiomers, or diastereomers thereof.