Fused pyrimidinedione derivatives as trpa1 modulators, compositions comprising them and use thereof for preparation of medicaments

摘要

The present invention relates to a process for preparing a compound of formula (Id-1)
or a pharmaceutically acceptable salt thereof, which comprises
reacting a compound of formula (35) with amine compound of formula (18)
wherein,
R 1 and R 2 , which may be same or different, are independently selected from hydrogen and substituted or unsubstituted alkyl;
U is substituted or unsubstituted heterocycles selected from thiazole and isoxazole; and
V is substituted or unsubstituted aryl.