NOVEL FGFR3 FUSION

摘要

[Problem] The present invention aims to elucidate a polynucleotide as a novel responsible gene for cancer and aims to thus provide a method for detecting the polynucleotide and a polypeptide encoded by the polynucleotide and a detection kit, a probe set, and a primer set for the detection. The present invention also aims to provide a pharmaceutical composition for treating cancer.;[Means for Solution] The method detects a fusion gene composed of a portion of an FGFR3 gene and a portion of a TACC3 gene or a fusion protein encoded by the fusion gene. The primer set, the probe set, or the detection kit comprises a sense primer and a probe set designed from the portion encoding FGFR3 and an antisense primer and a probe set designed from the portion encoding TACC3. Since an inhibitor of the polypeptide exhibits antitumor effect, a pharmaceutical composition for treating cancer which is positive for either the fusion gene or the polypeptide is provided.

主权项

1. A method for detecting a fusion gene composed of a fibroblast growth factor receptor 3 (FGFR3) gene and a transforming acidic coiled-coil containing protein 3 (TACC3) gene or a fusion protein composed of FGFR3 and TACC3, which comprises detecting the existence of either a polynucleotide encoding the following polypeptide or the polypeptide in a specimen obtained from a test subject:
A polypeptide which has tumorigenicity and comprises an amino acid sequence having 90% or more identity to the amino acid sequence represented by amino acid numbers 461 to 947 of SEQ ID NO: 2, amino acid numbers 461 to 982 of SEQ ID NO: 4, amino acid numbers 461 to 996 of SEQ ID NO: 6, amino acid numbers 461 to 1043 of SEQ ID NO: 26, or amino acid numbers 461 to 1040 of SEQ ID NO: 28.