发明名称 |
INHIBITORS OF TRANSCRIPTION FACTORS AND USES THEREOF |
摘要 |
The present invention provides novel compounds of any one of Formulae (I) to (IV), and pharmaceutically compositions thereof. Compounds of any one of Formulae (I) to (IV) are believed to be inhibitors of bromodomain-containing proteins (e.g., bromo and extra terminal proteins (BETs)). Also provided are methods, uses, and kits using the inventive compounds and pharmaceutical compositions for inhibiting the activity of the bromodomain-containing proteins and for treating and/or preventing in a subject in need thereof diseases associated with bromodomain-containing proteins, such as proliferative diseases. |
申请公布号 |
CA2918910(A1) |
申请公布日期 |
2015.01.29 |
申请号 |
CA20142918910 |
申请日期 |
2014.07.25 |
申请人 |
DANA-FARBER CANCER INSTITUTE, INC.;UNIVERSITY OF MASSACHUSETTS |
发明人 |
MARINEAU, JASON J.;BRADNER, JAMES E.;ZHANG, WEI;QI, JUN;MCKEOWN, MICHAEL R.;FU, HARRY HONGNING;LIU, SHUAI |
分类号 |
A61K31/519;A01N43/40;A01N43/54;C07D401/00 |
主分类号 |
A61K31/519 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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