CHEMICALLY MODIFIED CELL-PENETRATING PEPTIDES FOR IMPROVED DELIVERY OF GENE MODULATING COMPOUNDS

摘要

PROBLEM TO BE SOLVED: To provide a system for intracellular cargo delivery comprising a new series of molecules that overcome the described drawbacks for non-covalent gene-delivery, ie low and heterogeneous delivery as well as toxicity, without requiring biocleavable linkers to cleave chloroquine analogues, and comprising irreversibly chloroquine-coupled compounds.SOLUTION: The present invention relates to a system for intracellular cargo delivery comprising at least one component A comprising at least one aliphatic linear or branched moiety with at least 4 carbon atoms, wherein the component A is attached to a cell penetrating peptide B which is selected from LLOOLAAAALOOLL [SEQ ID No 6], AGYLLGKLLOOLAAAALOOLL [SEQ ID No 2], INLKALAALAKKIL[SEQ ID No 28 ], and AGYLLGKINLKALAALAKKIL [SEQ ID No 1], and deletions, additions insertions and substitutions of amino acids.