发明名称 |
TRANSGENIC ANIMAL MODEL OF MOOD DISORDERS |
摘要 |
A non-human transgenic animal having a polynucleotide encoding a PTN polypeptide, which polynucleotide is operably linked to a promoter, wherein said transgenic animal has greater than wild-type expression of the PTN polypeptide in at least one brain region, as well as related vectors, methods of producing transgenic animals, in vitro and in vivo screening methods for potential therapeutic agents, and methods for treating and diagnosing neuropsychiatric illnesses, particularly anxiety and depression, are disclosed. |
申请公布号 |
EP2827706(A1) |
申请公布日期 |
2015.01.28 |
申请号 |
EP20130711608 |
申请日期 |
2013.03.14 |
申请人 |
BRAINCO BIOPHARMA, S.L. |
发明人 |
ARTETA, DAVID;FERRER, MARCELO;SIMÓN, LAUREANO;MARTINEZ, ANTONIO;URIBARRI, MARIA |
分类号 |
A01K67/027;C07K14/475;C07K16/22;C12N15/113;C12N15/85;C12Q1/68;G01N33/50;G01N33/68 |
主分类号 |
A01K67/027 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|