发明名称 |
JCV NEUTRALIZING ANTIBODIES |
摘要 |
In one aspect, the disclosure provides neutralizing antibodies against JCV and methods for the treatment of PML. In some embodiments, aspects of the invention relate to an isolated JC-vims neutralizing monoclonal antibody against JCV capsid protein VPI (JCV-VP1). In some embodiments, the antibody suppresses infectivity of the JC-vims. In some embodiments, the antibody binds the sialic acid binding pocket of JCV-VP1. |
申请公布号 |
EP2828284(A1) |
申请公布日期 |
2015.01.28 |
申请号 |
EP20130765090 |
申请日期 |
2013.03.15 |
申请人 |
BIOGEN IDEC MA INC. |
发明人 |
SIMON, KENNETH;CAMERON, THOMAS;WANG, DEPING;ARNDT, JOSEPH;RUSHE, MIA;CARAVELLA, JUSTIN;DAY, ERIC |
分类号 |
C07K14/24 |
主分类号 |
C07K14/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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