Optical Resolution Methods for Bicyclic Compounds Using Enzymes

摘要

An object of the present invention is to efficiently produce an optically active bicyclic compound. The optically active bicyclic compound is efficiently produced using an enzyme.

主权项

1. A method of producing a compound of formula (I) or a compound of formula (II): comprising: (1) allowing a mixture of the compound of formula (I) and the compound of formula (II) to react in the presence of:
a reductase or an alcohol dehydrogenase,a coenzyme, anda compound selected from formic acid or a salt thereof, and/e glucose, and a combination thereof, in a buffer solution to convert either the compound of formula (I) to a compound of formula (I′) or the compound of formula (II) to a compound of formula (II′): wherein R1 is a hydrogen atom or a C1-C6 alkyl group, and (2) separating the compound of formula (I) from the compound of formula (II′) or separating the compound of formula (II) from the compound of formula (I′) to produce the compound of formula (I) or the compound of formula (II).