Peptides involved in the SCF c-Kit signaling pathway and compositions comprising same

摘要

Peptide compounds of general formula (I) R1-(AA)n-X1—X2—X3-Asp-Leu-Lys-Lys-X4—X5-(AA)p-R2, cosmetic or pharmaceutical compositions comprising at least one peptide compound of general formula (I) in a physiologically acceptable medium, and methods for cosmetic treatment of skin are disclosed. The peptide compounds of general formula (I) were demonstrated to be agents making it possible to influence the pigmentation of the skin and skin appendages, by ensuring optimal transfer of the melanosomes to the keratinocytes, so as to make the skin tone uniform owing to an effect on the SCF/c-Kit signaling pathway. The compounds, compositions, and methods treat or attenuate age-related pigmentation defects and the effects of photoaging on the skin.

主权项

1. A peptide compound having one of the following sequences selected from the group consisting of:(SEQ ID NO: 1)Ser-Cys-Arg-Asp-Leu-Lys-Lys-Thr-NH2;(SEQ ID NO: 2)Asn-Ser-Ser-Lys-Asp-Leu-Lys-Lys-Phe-Val-Ala-NH2(SEQ ID NO: 3)Cys-Lys-Asp-Leu-Lys-Lys-Ser-Phe;(SEQ ID NO: 4)Gln-Thr-Arg-Asp-Leu-Lys-Lys-Ser-Pro-Lys-Val-NH2;(SEQ ID NO: 5)Asn-Lys-Asp-Leu-Lys-Lys-Pro-Met;(SEQ ID NO: 6)His-Asp-Leu-Lys-Lys-Tyr-NH2; or(SEQ ID NO: 7)Asp-Leu-Lys-Lys-NH2.