| 摘要 |
The present invention relates to a novel trans-2-decenoic acid derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical agent containing the compound as an active ingredient. The trans-2-decenoic acid derivative or a pharmaceutically acceptable salt, which is the compound of the present invention, is specifically represented by the general formula (I):;;wherein X is a substituent such as a 1-pyrrolidyl, a 3-thiazolizyl, or a piperidino, and the compound is highly useful as a pharmaceutical agent, such as a prophylactic or therapeutic agent for a peripheral nerve disorder induced by administration of an anticancer agent, a prophylactic or therapeutic agent for neurodegenerative diseases or mental diseases such as dementia, Alzheimer's disease, Parkinson's disease, diabetic neuropathy, depression, glaucoma, or autistic disorder spectrum, a therapeutic or repairing agent for spinal cord injury, analgesics against various pain diseases, or the like. |
| 主权项 |
1. A trans-2-decenoic acid derivative represented by the following general formula (I′) or a pharmaceutically acceptable salt thereof: wherein X′ is: (a) a 1-pyrrolidyl substituted with carboxyl or alkoxycarbonyl, (b) a 3-thiazolidyl, (c) a piperidino substituted with alkyl, oxo, hydroxy, alkoxy, carboxyl, alkoxycarbonyl, alkylamino, alkylaminoalkyl, phenyl, carboxyalkyl, alkoxycarbonylalkyl, cyano, or halogenophenyl, (d) a thiomorpholino, (e) a 1-piperazyl which may be substituted with alkyl, carboxyalkyl, alkoxycarbonylalkyl, alkylaminoalkyl, cycloalkyl, piperidinoalkyl, phenylalkyl, pyridyl, pyrimidyl, carboxyphenylalkyl or alkoxycarbonylphenylalkyl, (f) a 1-piperazyl substituted with a phenyl which may be substituted with alkylamino, halogen, alkoxy, alkyl, hydroxy, carboxyalkoxy or alkoxycarbonylalkoxy, (g) a 1,4-diazepanyl which may be substituted with alkyl or alkylaminoalkyl, or (h) a carboxymorpholino. |
