IMIDAZOLE DERIVATIVES AS INHIBITORS OF PDE10

摘要

A compound of formula (I) pharmaceutical^ acceptable salt thereof, wherein Rl is selected from hydrogen, Ci-C6 alkyl; Ci-C6 alkyl(C3-C8)cycloalkyl; Ci- C6 hydroxyalkyl; CH2CN; CH2C(0)NH2; Ci-C6 arylalkyl; and Ci-C6 10 alkylheterocyclylalkyl; R'-R° are independently selected from hydrogen, Ci-Ce alkoxy; and halo; and 7 R is a heteroaromatic group of formula (II) containing from 2 to 4 nitrogen atoms: Y^Z C3I6>