The present invention relates to a multiplex editing system. The system allows multiple editing of nucleic acid sequences such as genomic sequences, such as knockins of genes of interest in a genome, knockouts of genomic sequences and/or allele replacement. Also provided herein are a method for editing nucleic acids and a cell comprising a stably integrated endonuclease.
申请公布号
WO2015052231(A2)
申请公布日期
2015.04.16
申请号
WO2014EP71534
申请日期
2014.10.08
申请人
TECHNICAL UNIVERSITY OF DENMARK
发明人
PEDERSEN, LASSE EBDRUP;RONDA, CARLOTTA;KILDEGAARD, HELENE FAUSTRUP;LEE, JAE SEONG