Antibodies and antigen binding fragments that specifically binds to Siglec-15 are described herein. These antibodies or antigen binding fragments may have the ability of inhibiting differentiation of osteoclasts and/or the ability of inhibiting the bone resorption activity of osteoclasts. Compositions and cells expressing anti-Siglec-15 antibodies or antigen binding fragments are also disclosed herewith. Anti-Siglec-15 antibodies may also be useful for the treatment of bone loss, or bone diseases. Methods for the detection or diagnosis of bone loss or bone-related diseases are also described.
申请公布号
IN2933KON2014(A)
申请公布日期
2015.05.08
申请号
IN2014KOLNP2933
申请日期
2014.12.15
申请人
ALETHIA BIOTHERAPEUTICS INC.
发明人
STUIBLE, MATTHEW;TREMBLAY, GILLES, BERNARD;SULEA, TRAIAN;MORAITIS, ANNA, N.;FILION, MARIO