PYRIDINYL-SUBSTITUTED PYRAZOLYL CARBOXAMIDES

摘要

The invention relates to pyrazolyl-based carboxamide compounds useful as ICRAC inhibitors, to pharmaceutical compositions containing these compounds and to methods of using these compounds for the treatment and/or prophylaxis of diseases and/or disorders, in particular inflammatory diseases and/or inflammatory disorders.

主权项

1. A compound of formula (I): wherein R1 denotes H, C1-4-alkyl or C3-6-cycloalkyl; R2 denotes H; F; Cl; Br; CN; CF3; CF2H; CFH2; C1-4-alkyl; OH; O—C1-4-alkyl; NH2; N(H)C1-4-alkyl; or N(C1-4-alkyl)2; L represents bond, O, C1-4-alkylene, C1-4-alkylene-O or O—C1-4-alkylene; R3 is selected from the group consisting of Cl, OH, CN; CF3; CF2H; CFH2; C1-4-alkyl; C3-6-cycloalkyl; 3 to 7 membered heterocycloalkyl; 5- to 6-membered heteroaryl; C(═O)OH; C(═O)O—C1-4-alkyl; C(═O)NH2; C(═O)N(H)C1-4-alkyl; C(═O)N(C1-4-alkyl)2; O—C1-4-alkyl; OCF3; OCF2H; OCFH2; NH2; N(H)C1-4-alkyl; N(C1-4-alkyl)2; NH(C═O)(C1-4-alkyl); N(C1-4-alkyl)(C═O)(C1-4-alkyl); N(H)S(═O)2(C1-4-alkyl); N(C1-4-alkyl)S(═O)2(C1-4-alkyl); S(═O)2C1-4-alkyl; S(═O)C1-4-alkyl; S(═O)2NH2; S(═O)2N(H)C1-4-alkyl; and S(═O)2N(C1-4-alkyl)2; R4, R5 and R6 are independently selected from the group consisting H; F; Cl; Br; CN; CF3; CF2H; CFH2; C1-4-alkyl; C3-6-cycloalkyl; 3 to 7 membered heterocycloalkyl; OH; O—C1-4-alkyl; OCF3; OCF2H; OCFH2; OC3-6-cycloalkyl; O-(3 to 7 membered heterocycloalkyl); NH2; N(H)C1-4-alkyl; N(C1-4-alkyl)2; and NH(C═O)(C1-4-alkyl); and A represents phenyl or 5- to 6-membered heteroaryl, wherein
said heteroaryl, cycloalkyl and heterocycloalkyl each independently are unsubstituted or mono- or polysubstituted; and wherein
said C1-4-alkyl and C1-4-alkylene each independently are linear or branched, and each independently are unsubstituted or mono- or polysubstituted; optionally in the form of a single stereoisomer or a mixture of stereoisomers, in the form of the free compound and/or a physiologically acceptable salt thereof and/or a physiologically acceptable solvate thereof.