发明名称 COMPOUNDS FOR THE TREATMENT OF MTOR PATHWAY RELATED DISEASES
摘要 The present invention relates to compounds for the treatment of mTOR (mammalian Target Of Rapamycin) pathway related diseases. Specifically, the present invention relates to the use of aminoactonitrile derivatives (AADs) in the treatment of mTOR pathway related diseases.
申请公布号 US2015166477(A1) 申请公布日期 2015.06.18
申请号 US201314420081 申请日期 2013.08.05
申请人 Pitney Pharmaceuticals Pty Limited ;Newsouth Innovations Pty Limited 发明人 Pourgholami Mohammad Hossein;Morris David L.;Aston Roger
分类号 C07C323/62;C07C255/62;C07C317/44 主分类号 C07C323/62
代理机构 代理人
主权项 1. A compound of formula (I): or a metabolite, pharmaceutically acceptable salt, solvate or prodrug thereof, for the treatment of one or more mTOR pathway related diseases, wherein, R1, R2 and R3 and R5 are each independently selected from H, alkyl, halogen, —CF3 or —CN; R4 and R6 are each independently selected from H, alkyl, halogen, alkoxy, —CF3, —OCF3, —SO2CF3, —SOCF3 or —SCF3; X is heteroatom, N(alkyl) or NH; and n is 1 to 20.
地址 Kogarah AU
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