ABSORBABLE POLYMERIC BLEND COMPOSITIONS BASED ON COPOLYMERS PREPARED FROM MONO- AND DI-FUNCTIONAL POLYMERIZATION INITIATORS, PROCESSING METHODS, AND MEDICAL DEVICES THEREFROM

摘要

Novel absorbable polymeric blends made from components wherein at least one of the components is synthesized using mixtures of mono- and di-functional initiators are disclosed. The blends have a first component that is a polylactide polymer or a copolymer of lactide and glycolide and a second component that is either poly(p-dioxanone) homopolymer, or a poly(p-dioxanone-co-glycolide) copolymer. The novel polymeric blends provide medical devices having dimensional stability. Also disclosed are novel absorbable medical devices made from these novel polymer blends, as well as novel methods of manufacture.

主权项

1. An absorbable polymer blend, comprising:
a first absorbable polymer, the first polymer comprising at least 50 weight percent of a lactide-rich polymer comprising about 95 mole percent to about 70 mole percent polymerized lactide and about 5 mole percent to about 30 mole percent polymerized glycolide, wherein the first absorbable polymer is synthesized using a mixture of mono- and di-functional initiators, and wherein the molar ratio of mono-functional to di-functional initiator is from about 10:90 to about 90:10; and, a second absorbable polymer, the second polymer comprising poly(p-dioxanone), wherein the maximum weight percent of poly(p-dioxanone) in the blend is 50 weight percent and the minimum weight percent of poly(p-dioxanone) in the blend is sufficient such that the polymer blend effectively provides dimensional stability to a manufactured article,