| 发明名称 | Methods for diagnosing and treating neuroendocrine cancer | ||
| 摘要 | The present invention relates to a method for diagnosing neuroendocrine cancers via detecting the presence of N-methyl D-asparate-associated (NMDA) glutamate receptors type 1 and/or type 2. Methods for preventing and treating neuroendocrine cancers are also disclosed. | ||
| 申请公布号 | US9084775(B2) | 申请公布日期 | 2015.07.21 |
| 申请号 | US201313895682 | 申请日期 | 2013.05.16 |
| 申请人 | Trustees of Dartmouth College | 发明人 | North William G. |
| 分类号 | C12Q1/00;A61K39/395;C07K16/28;C12N15/113;C12Q1/68;G01N33/574 | 主分类号 | C12Q1/00 |
| 代理机构 | Licata & Tyrrell P.C. | 代理人 | Licata & Tyrrell P.C. |
| 主权项 | 1. A method for affecting the proliferation of a neuroendocrine tumor cell comprising contacting a neuroendocrine tumor cell, wherein the neuroendocrine tumor cell comprises a small cell lung, ovarian or pancreatic tumor cell, with an effective amount of an antagonist of an NMDA glutamate receptor that selectively inhibits an NMDA glutamate type 2 receptor, and further wherein said antagonist inhibits or decreases the expression of the NMDA glutamate type 2 receptor or antagonizes the glutamate site, glycine site, polyamine site or channel pore of the NMDA glutamate type 2 receptor and inhibits or decreases NMDA glutamate type 2 receptor activity; and measuring the proliferation of the neuroendocrine tumor cell, wherein decreased proliferation results from the inhibition of the NMDA glutamate type 2 receptor. | ||
| 地址 | Hanover NH US | ||