| 发明名称 | T-cell immunogens derived from anti-viral proteins and methods of using same | ||
| 摘要 | Isolated polypeptides related to endogenous anti-viral polypeptides; and compositions, including immunogenic compositions, comprising a subject isolated polypeptide are disclosed herein. A subject isolated polypeptide comprises an amino acid sequence having substantial amino acid sequence identity to a contiguous stretch of amino acids of one or more endogenous anti-viral polypeptides, wherein the endogenous anti-viral polypeptides are polypeptides subject to proteolytic degradation as a result of the activity of one or more viral proteins. Also provided are diagnostic and treatment methods using the subject isolated polypeptides and compositions. | ||
| 申请公布号 | US9084762(B2) | 申请公布日期 | 2015.07.21 |
| 申请号 | US200913121106 | 申请日期 | 2009.09.28 |
| 申请人 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 发明人 | Nixon Douglas F.;Champiat Stephane;Garrison Keith |
| 分类号 | A61K38/08;A61K38/10;A61K39/00;C07H21/00;C07K7/06;C07K7/08;C07K14/435;A61K39/21;C07K14/005;C07K14/16;A61K38/16 | 主分类号 | A61K38/08 |
| 代理机构 | Bozicevic, Field & Francis LLP | 代理人 | Bozicevic, Field & Francis LLP ;Borden Paula A. |
| 主权项 | 1. A method of inducing a T lymphocyte response in an individual to a host cell infected with a human immunodeficiency virus (HIV), the method comprising administering to the individual an immunogenic composition comprising a nucleic acid encoding a polypeptide consisting of from 9 amino acids to about 150 amino acids, wherein said polypeptide comprises the amino acid sequence of one of SEQ ID NOs:11-14, and 16. | ||
| 地址 | Oakland CA US | ||