SYNTHETIC PEPTIDES WTIH A NON NARCOTIC TYPE OF ANALGESIC EFFECT

摘要

?What are proposed are: synthetic peptides having a non narcotic type of analgesic effect of general formula 1 [SEQ ID NO:1] where: H is hydrogen XDL is an omission of an amino acid or is L Tyr XDL1 is one of the following amino acids: L Leu L Ala or D Ala XDL2 is one of the following amino acids: L His D His L Ala or D Ala XDL3 is one of the following amino acids: L Gln L Ala or D Ala; R2 is ??? or NH2 and also retro inversion peptides of formula (I) having a reverse sequence of amino acids with L shaped amino acids being substituted by D shaped amino acids and D shaped amino acids being substituted by L shaped amino acids of general formula 2 [SEQ ID NO:2] where: H is hydrogen XDL4 is one of the following amino acids: D GIn D Ala or L Ala XDL5 is one of the following amino acids: D His L His D Ala or L Ala XDL6 is one of the following amino acids: D Leu D Ala or L Ala XDL7 is an omission of an amino acid or is D Tyr R2 is ??? or NH2.