发明名称 |
(4-PHENYL-PIPERIDIN-1-YL)-[5-1H-PYRAZOL-4YL)-THIOPHEN-3-YL]-METHANONE COMPOUNDS AND THEIR USE |
摘要 |
<p>The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain (4-phenyl-piperidin-1-yl)-[5-(1H-pyrazol-4-yl)-thiophen-3-yl]-methanone compounds that, inter alia, inhibit 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit 11ß-hydroxysteroid dehydrogenase type 1; to treat disorders that are ameliorated by the inhibition of 11ß-hydroxysteroid dehydrogenase type 1; to treat the metabolic syndrome, which includes disorders such as type 2 diabetes and obesity, and associated disorders including insulin resistance, hypertension, lipid disorders and cardiovascular disorders such as ischaemic (coronary) heart disease; to treat CNS disorders such as mild cognitive impairment and early dementia, including Alzheimer's disease; etc.</p> |
申请公布号 |
IN2590DEN2012(A) |
申请公布日期 |
2015.08.28 |
申请号 |
IN2012DE02590 |
申请日期 |
2012.03.23 |
申请人 |
THE UNIVERSITY OF EDINBURGH |
发明人 |
WEBSTER, SCOTT PETER;SECKL, JONATHAN ROBERT;WALKER, BRIAN ROBERT;WARD, PETER;PALLIN, THOMAS DAVID;DYKE, HAZEL JOAN;PERRIOR, TREVOR ROBERT |
分类号 |
C07D409/14 |
主分类号 |
C07D409/14 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|