Class of HDAC Inhibitors Expands the Renal Progenitor Cells Population and Improves the Rate of Recovery from Acute Kidney Injury

摘要

Compounds and compositions are provided that inhibit histone deacylase activity and which expand renal progenitor cell populations and improve kidney function in a damaged kidney. Methods of use of the compounds and compositions are provided.

主权项

1. A compound having the formula: in which R is S, R1 is —NHR4 where R4 is OH, 2-aminophenyl, or 2-hydroxyphenyl, R2 is phenyl, 2-chlorophenyl, or 3-chlorophenyl, and R3 is —CH2—CH2—CH2— or —CH2—CH2—CH2—CH2—CH2—, wherein when R2 is phenyl, R4 is 2-hydroxyphenyl and when R2 is 3-chlorophenyl, and R3 is —CH2—CH2—CH2—CH2—CH2—, R4 is OH or 2-aminophenyl, or a pharmaceutically acceptable salt thereof.