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1. A compound having the formula:or a pharmaceutically acceptable salt thereof, wherein:
A is:wherein A can be joined to the benzofuran moiety of formula (I) via any of group A's ring carbon atoms;
L is N or CH; M is N or CH; Q is —CH(R4b); U is —N(R5)—, O, S or —C(R4b)2—; V is —N— or —C(R4a)—; W is —N— or —C(R4)—, or the group —W═V—U— is —NH—C(O)—N(R5)— one of Y1 and Y2 is —N— or —C(R10)—, and the other of Y1 and Y2 is a carbon atom and represents the point of attachment of the benzofuran moiety depicted in formula (I); X and Z are each independently —N— or —C(R10)—; R1 represents up to 4 optional ring substituents, which can be the same or different, and are independently selected from halo, C1-C6 alkyl, C1-C6 haloalkyl, phenyl, 3 to 7-membered monocyclic cycloalkyl, —O—(C1-C6 alkyl), —O—(C1-C6 haloalkyl) and —CN; R2 is —C(O)N(R6)(R7); R3 is 5 or 6-membered heterocycloalkyl or —N(R8)—S(O)n—R9, wherein said 5 or 6-membered heterocycloalkyl can optionally have one of its ring carbon atoms replaced with a carbonyl group; R4 is selected from H, halo, C1-C6 alkyl, C1-C6 haloalkyl, —O—(C1-C6 alkyl), —O—(C1-C6 haloalkyl), C1-C6 hydroxyalkyl, —C(O)O—(C1-C6 alkyl), —(C1-C6 alkylene)r-aryl, —(C1-C6 alkylene)r-(3 to 7-membered monocyclic cycloalkyl), —(C1-C6 alkylene)n-(4 to 7-membered monocyclic heterocycloalkyl), —(C1-C6 alkylene)n-(5 or 6-membered monocyclic heteroaryl) and —(C1-C6 alkylene)r-(9 or 10-membered bicyclic heteroaryl), wherein said aryl group, said 3 to 7-membered monocyclic cycloalkyl group, said 4 to 7-membered monocyclic heterocycloalkyl group, said 5 or 6-membered monocyclic heteroaryl group and said 9 or 10-membered bicyclic heteroaryl group can be optionally substituted with up to 3 groups, which can be the same or different, and are selected from halo, C1-C6 alkyl, C1-C6 haloalkyl, phenyl, 3 to 7-membered monocyclic cycloalkyl, —O—(C1-C6 alkyl), —O—(C1-C6 haloalkyl), —S(O)2—(C1-C6 alkyl), —C(O)O—(C1-C6 alkyl), C1-C6 hydroxyalkyl and —CN; R4a is selected from H, C1-C6 alkyl, 3 to 7-membered cycloalkyl, phenyl and 5 or 6-membered monocyclic heteroaryl, wherein said 3 to 7-membered cycloalkyl group, said phenyl group and said 5 or 6-membered monocyclic heteroaryl group can be optionally substituted with up to 2 groups, which can be the same or different, and are selected from C1-C6 alkyl, C1-C6 haloalkyl, halo, —CN, —O—(C1-C6 alkyl) and —O—(C1-C6 haloalkyl); each occurrence of R4b is independently selected from H, C1-C6 alkyl, 3 to 7-membered cycloalkyl, phenyl and 5 or 6-membered monocyclic heteroaryl, wherein said 3 to 7-membered cycloalkyl group, said phenyl group and said 5 or 6-membered monocyclic heteroaryl group can be optionally substituted with up to 2 groups, which can be the same or different, and are selected from C1-C6 alkyl, C1-C6 haloalkyl, halo, —CN, —O—(C1-C6 alkyl) and —O—(C1-C6 haloalkyl); each occurrence of R5 is independently selected from H, C1-C6 alkyl, C1-C6 hydroxyalkyl, —C(O)O—(C1-C6 alkyl), —(C1-C6 alkylene)r-phenyl, —(C1-C6 alkylene)r-(3 to 7-membered monocyclic cycloalkyl), —(C1-C6 alkylene)r-(4 to 7-membered monocyclic heterocycloalkyl), —(C1-C6 alkylene)r-(5 or 6-membered monocyclic heteroaryl) and —(C1-C6 alkylene)r-(9 or 10-membered bicyclic heteroaryl), wherein said phenyl group, said 3 to 7-membered monocyclic cycloalkyl group, said 4 to 7-membered monocyclic heterocycloalkyl group, said 5 or 6-membered monocyclic heteroaryl group and said 9 or 10-membered bicyclic heteroaryl group can be optionally substituted with up to 3 groups, which can be the same or different, and are selected from halo, C1-C6 alkyl, C1-C6 haloalkyl, phenyl, 3 to 7-membered monocyclic cycloalkyl, —O—(C1-C6 alkyl), —O—(C1-C6 haloalkyl), —S(O)2—C1-C6 alkyl, —C(O)O—(C1-C6 alkyl), C1-C6 hydroxyalkyl and —CN; R6 and R7 are each independently selected from hydrogen, C1-C6 alkyl, phenyl, 3 to 7-membered monocyclic cycloalkyl, 3 to 7-membered monocyclic heterocycloalkyl and 5 or 6-membered monocyclic heteroaryl; and R8 is selected from H, C1-C6 alkyl and 3 to 7-membered monocyclic cycloalkyl; R9 is selected from H, C1-C6 alkyl, C1-C6 haloalkyl, phenyl, 3 to 7-membered monocyclic cycloalkyl, 3 to 7-membered monocyclic heterocycloalkyl and 5 or 6-membered monocyclic heteroaryl; each occurrence of R10 is independently selected from H, halo, C1-C6 alkyl, C1-C6 haloalkyl, —O—(C1-C6 alkyl), —O—(C1-C6 haloalkyl) and —CN; each occurrence of n is independently 1 or 2; and each occurrence of r is independently 0 or 1. |
