| 发明名称 |
SUBSTITUTED DIAMINOPYRIMIDYL COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH |
| 摘要 |
Provided herein are diaminopyrimidyl Compounds having the following structures:;wherein X, L, R1, and R2 are as defined herein, compositions comprising an effective amount of a Diaminopyrimidyl Compound, and methods for treating or preventing PKC-theta-mediated disorders, or a condition treatable or preventable by inhibition of a kinase, for example, PKC-theta. |
| 申请公布号 |
US2015246890(A1) |
申请公布日期 |
2015.09.03 |
| 申请号 |
US201514680530 |
申请日期 |
2015.04.07 |
| 申请人 |
Signal Pharmaceuticals, LLC |
发明人 |
BAHMANYAR Sogole;CALABRESE Andrew Antony;CASHION Daniel;CATHERS Brian Edwin;CORREA Matthew;DELGADO Maria Mercedes;HANSEN Joshua;HEGDE Sayee;HUANG Dehua;LEFTHERIS Katerina;MORTENSEN Deborah;NORRIS Stephen;PAPA Patrick;PARNES Jason;PLANTEVIN-KRENITSKY Veronique;RAHEJA Raj Kumar;SAPIENZA John;TORRES Eduardo;WHITEFIELD Brandon Wade |
| 分类号 |
C07D239/48;C07D403/12;C07D405/14;C07D413/12;C07D405/12;C07D471/04;C07D401/12;C07D409/12 |
主分类号 |
C07D239/48 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A compound of formula (I): or a pharmaceutically acceptable salt, tautomer, isotopologue, or stereoisomer thereof, wherein: X is CN; L is CH2; R1 is substituted or unsubstituted heteroaryl; and R2 is substituted cyclohexyl. |
| 地址 |
San Diego CA US |
