| 发明名称 |
IMMUNE PRIVILEGED AND MODULATORY PROGENITOR CELLS |
| 摘要 |
Described herein is a method for modulating an immune reaction between lymphocytes and a body recognized by the lymphocytes as foreign. The method exploits the immunomodulating activity of a new class of progenitor cells termed HUCPVCs derived from the perivascular region of human umbilical cord. The method can also employ soluble factors exuded by cultured HUCPVCs. The method is useful to treat immune disorders including graft versus host disease, autoimmune disorders, and the like. |
| 申请公布号 |
US2015246079(A1) |
申请公布日期 |
2015.09.03 |
| 申请号 |
US201414554932 |
申请日期 |
2014.11.26 |
| 申请人 |
DAVIES John E.;ENNIS Jane E.;GOMEZ-ARISTIZABAL Alejandro;BAKSH Dolores |
发明人 |
DAVIES John E.;ENNIS Jane E.;GOMEZ-ARISTIZABAL Alejandro;BAKSH Dolores |
| 分类号 |
A61K35/51 |
主分类号 |
A61K35/51 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A method for modulating an immune reaction between lymphocytes and a body recognized by the lymphocytes as foreign, comprising the step of introducing, in an amount effective to inhibit or reduce said immune reaction, an agent selected from (1) umbilical cord perivascular cells, and/or (2) an immunomodulating soluble factor produced by said cells. |
| 地址 |
Toronto CA |
