METHODS FOR INHIBITING TIE-2 KINASE USEFUL IN THE TREATMENT OF CANCER

摘要

The present invention relates to methods of inhibiting TIE2 kinase useful in the treatment of tumor growth, invasiveness, intravasation, dissemination, metastasis, and immunosuppression. Specifically, the invention relates to methods of using 1-(3-tert-butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea and salts thereof of Formula I.

主权项

1. A method of blocking primary breast tumor growth and invasiveness comprising administering to a patient in need thereof an effective amount of a composition of Formula I wherein
n is an integer from 0 to 7;X is the basic radical of a pharmaceutically acceptable salt;provided that when n is 0, the composition of Formula I is the parent free base; in a dosing regimen sufficient to block TIE2 kinase in the tumor microenvironment.