发明名称 |
IMPROVED METHOD FOR SYNTHESIZING PIRFENIDONE |
摘要 |
A process for synthesizing pirfenidone from bromobenzene having less than about 0.15% by weight dibromobenze is disclosed. Also disclosed are processes of synthesizing pirfenidone without using ethyl acetate or n-butanol, and pirfenidone having controlled levels of ethyl acetate, n-butanol, di(5-methyl-2-pyridinone)benzenes, and other impurities having specified retention times. |
申请公布号 |
EA021826(B1) |
申请公布日期 |
2015.09.30 |
申请号 |
EA20110001695 |
申请日期 |
2010.06.02 |
申请人 |
INTERMUNE, INC. |
发明人 |
RADHAKRISHNAN RAMACHANDRAN;CYR MIKE;BOUTET SABINE, MARIE-FRANCOISE, BRIGITTE |
分类号 |
C07D401/10;A61K31/4412;A61P9/00;C07D213/64 |
主分类号 |
C07D401/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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