| 摘要 |
The invention relates to a camptothecin derivative having a structure as represented by Formula (II), in which Xis selected from H, K, Na, Li, Mg, Ca, Zn, Fe, and ammonium ion, while R, R, R, and Rindependently represent a hydrogen, a hydroxyl group, a nitro group, a cyano group, a halogen, a carboxyl group, an optionally substituted amino group, a silicon-containing group, a monocyclic aryloxy group, an optionally substituted C-C-alkoxy group, an optionally substituted C-C-alkylcarbonyl group, an optionally substituted C-C-alkyl group, or an optionally substituted C-C-cycloalkyl group; alternatively, Rand Rare connected via 1 to 3 other atoms to form a heterocyclic ring; and in another embodiment, Rand Rare oxygen atoms and connected via -O-(CH)-O-, forming a ring, in which n=1 or 2. The compound has great water-solubility, chemical stability, and great efficacy in treatment of cancer. |
