| 发明名称 |
NOVEL TETRAGALNAC CONTAINING CONJUGATES AND METHODS FOR DELIVERY OF OLIGONUCLEOTIDES |
| 摘要 |
Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or different; optionally, 3) one or more linkers, which may be the same or different; and optionally, 4) one or more targeting ligands, solubilizing agents, pharmacokinetics enhancing agents, lipids, and/or masking agents. |
| 申请公布号 |
EP2844663(A4) |
申请公布日期 |
2015.09.30 |
| 申请号 |
EP20130784779 |
申请日期 |
2013.05.01 |
| 申请人 |
SIRNA THERAPEUTICS, INC. |
发明人 |
TELLERS, DAVID;COLLETTI, STEVEN, L.;DUDKIN, VADIM;IKEMOTO, NORIHIRO;LIAO, HONGBIAO;PARISH, CRAIG;PEI, TAO;SHAW, ANTHONY;TRUONG, QUANG;WANG, LIJUN;YUAN, YU;ZHU, MAN |
| 分类号 |
C07H15/26;A61K47/48;C12N15/113 |
主分类号 |
C07H15/26 |
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