ETHYNYLATED HETERODINUCLEOSIDE PHOSPHATE ANALOGS, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF

摘要

Ethynylated hetero dinucleoside phosphate analogues (I), are new. Ethynylated hetero dinucleoside phosphate analogues of formula (N 1>-P(=X)(O ->Z +>)-N 2>) (I), are new. X : O or S; Z : H or an acid addition salt; and N 1>, N 2>a nucleoside group, where each of the nucleoside group exhibits a glycoside (or its diverted cyclic) residue and a covalently bonded base residue, the glycoside residue is covalently bonded with the central P atom (oxygen or sulfur link), and at least one of the nucleoside group exhibits an ethynylated glycoside residue. Independent claims are included for: (1) a pharmaceutical agent comprising (I) in a carrier or diluent; and (2) preparation of (I). ACTIVITY : Antimicrobial; Cytostatic; Virucide; Anti-HIV; Antiinflammatory; Hepatotropic. MECHANISM OF ACTION : None given.